Strategy for Improving Stroke Treatment Response
SISTER is a Phase-II, prospective, randomized, placebo-controlled, blinded, dose finding
trial that aims to determine the safety and preliminary efficacy of TS23, a monoclonal
antibody against the alpha-2 antiplasmin (a2-AP), in acute ischemic stroke.
Age: 18 years - 66+
Gender: All
Treatment With Endovascular Intervention for STroke Patients With Existing Disability
TESTED will compare the risks and benefits of endovascular thrombectomy (EVT) to medical management (no EVT) in ischemic stroke patients who have a blockage in one of the large blood vessels in the brain and have a moderate-to-severe disability prior to their stroke.
Age: 18 years - 66+
Gender: All
Vagal Nerve Stimulation in Enhanced Stroke Recovery: The VALOR Registry
Vagal Nerve Stimulation is a novel proven therapy for patients with chronic ischemic stroke.
The primary objective of this registry is to assess the safety of vagal nerve stimulation for
stroke recovery through monitoring the occurrence of serious adverse events ass...
Age: 18 years - 66+
Gender: All
A Study to Test Asundexian for Preventing a Stroke Caused by a Clot in Participants After an Acute Ischemic Stroke or After a High-risk Transient Ischemic Attack, a So-called Mini Stroke
Researchers are looking for a better way to prevent an ischemic stroke which occurs when a
blood clot travelled to the brain in people who within the last 72 hours had:
- an acute stroke due to a blood clot that formed outside the heart (acute
non-cardioembolic ...
Age: 18 years - 66+
Gender: All
Validation of Early Prognostic Data for Recovery Outcome After Stroke for Future, Higher Yield Trials
VERIFY will validate biomarkers of upper extremity (UE) motor outcome in the acute ischemic stroke window for immediate use in clinical trials, and explore these biomarkers in acute intracerebral hemorrhage. VERIFY will create the first multicenter, large-scale, prospec...
Age: 18 years - 66+
Gender: All
Distal Ischemic Stroke Treatment With Adjustable Low-profile Stentriever
The objective of the DISTALS Study is to evaluate the safety and effectiveness of the
Tigertriever 13 Revascularization Device in restoring blood flow in the neurovasculature by
removing thrombus in patients presenting within 24 hours of onset with an ischemic strok...
Age: 18 - 85 years
Gender: All
EndovaSCular TreAtment to imProve outcomEs for Medium Vessel Occlusions (ESCAPE-MeVO Trial)
Stroke occurs when a blood clot causes a blockage in a blood vessel (artery) within the
brain. This type of stroke is called an ischemic stroke and carries a high risk of disability
or death. Stroke must be treated very fast. Any delay of even 10 minutes can result ...
Age: 18 years - 66+
Gender: All
Comparison of Anti-coagulation and Anti-Platelet Therapies for Intracranial Vascular Atherostenosis
The primary goal of the trial is to determine if the experimental arms (rivaroxaban or
ticagrelor or both) are superior to the clopidogrel arm for lowering the 1-year rate of
ischemic stroke, intracerebral hemorrhage, or vascular death.
Age: 30 years - 66+
Gender: All
Amplatzer Amulet LAAO vs. NOAC
The objective of this trial is to evaluate the safety and effectiveness of the Amulet LAA
occluder compared to NOAC therapy in patients with non-valvular AF at increased risk for
ischemic stroke and who are recommended for long-term NOAC therapy.
The clinical in...
Age: 18 years - 66+
Gender: All
Endovascular Therapy for Low NIHSS Ischemic Strokes
This study will test the hypothesis that patients presenting within 8 hours of onset with
cerebral ischemia in the setting of proximal large vessel occlusions (LVO) and low baseline
NIHSS scores (0-5) will have better 90-day clinical outcomes (mRS distribution) with...
Age: 18 years - 66+
Gender: All
The Imperative Trial: Treatment of Acute Ischemic Stroke With the Zoom Reperfusion System
The trial is designed to assess the safety and efficacy of using the Zoom Reperfusion System
in subjects diagnosed with acute ischemic stroke and undergoing a thrombectomy procedure
within 8 hours of last known well.
Age: 18 years - 66+
Gender: All
CERENOVUS Neurothrombectomy Devices Registry
A post-market registry evaluating the EmboTrap® Revascularization Device and CERENOVUS Large
Bore Catheter/ EMBOVAC Aspiration Catheter in acute ischemic stroke patients with confirmed
intracranial large vessel occlusion.
Age: 18 years - 66+
Gender: All
Volumetric Integral Phase-shift Spectroscopy for Noninvasive Detection of Hemispheric Bioimpedance Asymmetry in Acute Brain Pathology
The purpose of this study is to assess the ability of the Fluids Monitor to detect
hemispheric bioimpedance asymmetry associated with acute brain pathology in patients
presenting with suspected Acute Ischemic Stroke (AIS).
Age: 18 years - 66+
Gender: All